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CDC: early figures show unvaccinated at much higher risk for monkeypox

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According to preliminary data released Wednesday by the Centers for Disease Control and Prevention (CDC), people who were eligible for a monkeypox vaccine but didn’t receive one were about 14 times more likely to be infected than those those who have been vaccinated.

Although extremely limited, the numbers offer a first glimpse of the real-world effectiveness of the Jynneos vaccine.

“These new data give us a degree of cautious optimism that the vaccine is working as intended,” CDC Director Rochelle Walensky told reporters.

But the numbers are based on data collected from just 32 states, and there’s no way to distinguish how much of the drop in cases is due to the vaccine alone and how much is due to behavioral changes in the most vulnerable populations.

The data is also based on people who received only a single dose of the vaccine. Relatively few people in the current outbreak have completed the recommended two-dose series, according to the CDC.

Infections continue to fall week by week, but there are currently more than 25,000 cases of monkeypox identified in all 50 states.

Health officials have seen protection from monkeypox for those vaccinated with Jynneos as early as two weeks after the first dose, Walensky said. However, she said laboratory studies show that immune protection is highest two weeks after the second dose of the vaccine, which is why they continue to strongly recommend people to get two doses of Jynneos 28 days apart.

“What we have at the moment is data on how well our vaccine works after a single dose. What we don’t know yet is what happens after a second dose and how durable that protection is,” Walensky said.

In addition to the initial numbers, health officials said Wednesday they are expanding eligibility for the Jynneos vaccine by moving to a pre-exposure prophylaxis strategy.

The new strategy “encourages vaccine providers to minimize the risk assessments of people seeking the vaccine. Fear of disclosure of sexuality and gender identity must not be a barrier to vaccination,” said Demetre Daskalakis, White House adviser on monkeypox.

Daskalakis said people who may be currently or in the future at risk are now eligible, including: gay, bisexual and other men who have sex with men; Transgender or gender-matched individuals who have had more than one sex partner in the past six months; Have had sex in a location associated with a higher risk of monkeypox or have been diagnosed with a sexually transmitted infection in the past six months.

The strategy also extends vaccines to sexual partners of at-risk individuals and commercial sex workers, Daskalakis said.

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AI ‘Simulants’ Could Save Time and Money on New Medications

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Nov. 30, 2022 – Artificial intelligence is poised to make clinical trials and drug development faster, cheaper, and more efficient. Part of this strategy is to create “synthetic control arms” that use data to create “simulants” or computer-generated “patients” in a study.

This allows researchers to enroll fewer real people and recruit enough participants in half the time.

Both patients and drug companies could benefit, say experts. For example, one benefit for people is that simulants receive standard treatment or placebo treatment, which means that everyone in the study ends up receiving the experimental treatment. For pharmaceutical companies unsure which of their drug candidates holds the most promise, AI and machine learning can narrow the prospects.

“Until now, machine learning has primarily been effective for optimizing efficiency – not for getting a better drug, but for optimizing screening efficiency. AI uses knowledge from the past to make drug discovery more effective and efficient,” says Dr. Angeli Moeller, Head of Data and Integrations Generating Insights at drugmaker Roche in Berlin and Deputy Chair of the Board of the Alliance for Artificial Intelligence in Healthcare.

“I’ll give you an example. You might have a thousand small molecules and you want to see which one binds to a receptor involved in a disease. With AI, you don’t have to screen thousands of candidates. Maybe you can only test a hundred,” she says.

“Synthetic” subjects

The first clinical trials to use data-generated matches for patients – instead of control patients who are matched by age, gender or other characteristics – have already started. For example, Imunon Inc., a biotechnology company developing next-generation chemotherapy and immunotherapy, used a synthetic control arm in its Phase 1B study an agent added to preoperative chemotherapy for ovarian cancer.

This early study showed the researchers that it would be worth pursuing the new compound further in a phase 2 trial.

Using a synthetic control arm is “extremely cool,” said Sastry Chilukuri, co-CEO of Medidata, the company that provided the data for the Phase 1B study, and founder and president of Acorn AI.

“What we have is the first FDA and EMA approval of a synthetic control arm, where you replace the entire control arm with synthetic control patients, and those are patients that you pull out from historical clinical trial data,” he says.

A wave of AI-supported research?

The role of AI in research is expected to increase. Until now, most AI-driven drug research has focused on neurology and oncology. The launch in these specialties is “probably due to the high unmet medical need and many well-characterized targets,” notes a March 2022 News and analysis piece in the diary Nature.

It has been speculated that this use of AI is just the beginning of a “coming wave”.

“There is increasing interest in using synthetic control methods [that is, using external data to create controls]”, so a review article in naturopathy in September.

The FDA already said so approved a drug in 2017 for a form of a rare pediatric neurological disorder, Batten disease, based on a study of historical control “participants.”

An example in oncology where a synthetic control arm could make a difference is in glioblastoma research, says Chilukuri. This brain tumor is extremely difficult to treat, and patients typically drop out of the trials because they want the experimental treatment and don’t want to stay in the standard-of-care control group, he says. Also, “given life expectancy, it’s very difficult to complete a study.”

Using a synthetic control arm could speed up research and improve the chances of completing a glioblastoma trial, Chilukuri says. “And the patients are actually getting the experimental treatment.”

Still early days

AI could also help limit “non-responders” in research.

Clinical trials “are really difficult, they’re time-consuming, and they’re extremely expensive,” says Naheed Kurji, chairman of the board of directors of the Alliance for Artificial Intelligence in Healthcare and president and CEO of Cyclica Inc, a data-driven drug discovery company based in Toronto.

“Companies are working very hard to find more efficient ways to bring AI into clinical trials so they can get results faster at lower cost but also higher quality.”

There are many clinical trials that fail, not because the molecule isn’t effective… but because the patients enrolled in a trial include many non-responders. They just delete the responder data,” says Kurji.

“You’ve heard a lot of people talk about how we’re going to make more progress in the next decade than in the last century,” says Chilukuri. “And that’s just because of this availability of high-resolution data that allows you to understand what’s happening at an individual level.”

“That’s going to start this explosion in precision medicine,” he predicts.

In a way, AI is still in its infancy in clinical research. Kurji says, “There’s still a lot to do, but I think you can point to a lot of examples and a lot of companies that have made really big strides.”

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CDC starting wastewater testing for polio in select communities

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The U.S. Centers for Disease Control and Prevention is expanding its sewage testing for polio in parts of Michigan and Pennsylvania, officials announced Wednesday.

Polio outbreaks once caused panic in the United States, but those concerns died down when a vaccine was developed and widely available in the 1950s and 1960s.

However, concerns about the spread of polio have been renewed this year after the first case of paralytic polio in nearly a decade was diagnosed in Rockland County, NY in July in an unvaccinated man.

Since then, New York health officials have uncovered 89 “interesting cases,” 82 of which have been linked to the infected Rockland man. The virus has been found in sewage from New York City, Orange County, Sullivan County, Queens County and Nassau County.

The CDC will begin wastewater testing in Michigan’s Oakland County and an unspecified area around Philadelphia.

“Sewage testing can be an important tool in understanding whether poliovirus is circulating in communities under certain circumstances,” said Dr. José R. Romero, director of the CDC’s National Center for Immunization and Respiratory Diseases. “Vaccination remains the best way to prevent another case of paralytic polio, and it is vital that people get vaccinated to protect themselves, their families and their communities from this devastating disease.”

Polio occurs in communities with low immunization rates, and the virus can spread quickly. One in four people who become infected with the virus eventually show flu-like symptoms such as diarrhea, fever, nausea, headaches and exhaustion.

However, according to the CDC, most people who contract the virus show no symptoms.

A smaller percentage of people will develop serious complications after contracting the virus.

There are two types of poliovirus vaccines. The first is a shot that can be administered in the leg or arm that has an inactivated spread of the virus, which has been present in the United States since 2000.

The second is the oral vaccine, which contains a weakened strain of the virus that is given via a few small drops in the mouth. The oral vaccine is widely available outside the United States, but in communities with low vaccination rates, this method can allow poliovirus to mutate, leading to the spread of vaccine-derived poliovirus.

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Know About The Best Fertility Doctor in Hyderabad.

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Having a baby and starting a family is a dream for many, but it becomes difficult for some couples who are trying to conceive but are unsuccessful. This condition is called infertility. There are various methods of treating infertility, but IVF is the most common among them. If you are also looking for treatment, we have mentioned a list of the best fertility doctors in Hyderabad, you can submit a query and we will accompany you through your treatment.

In vitro fertilization (IVF) is a complex set of procedures performed to aid fertility or prevent genetic problems and help conceive a child. During this procedure, mature eggs are removed from the ovaries and then fertilized with sperm in a laboratory. You need a responsible specialist and better equipment for this procedure to work.

In India it is possible receive affordable treatment by India’s top specialists through a simple process.

(One also likes to read: Premature ovarian failure: A condition that stops fertility )

Why is IVF done?

IVF is performed to treat infertility, the patient may be able to try less invasive treatment options before attempting IVF, including fertility drugs to increase egg production or intrauterine insemination, a procedure in which sperm are introduced into the uterus just before ovulation occurs.

Sometimes IVF is performed as the primary treatment for infertility in women over the age of 40. IVF can also be performed if the patient has certain health conditions.

  • endometriosis.
  • ovulation disorders.
  • uterine fibroids.
  • Unexplained infertility.
  • Previous tubal sterilization or removal.
  • Fallopian tube damage or blockage.

Cost of being treated by the best fertility doctor in Hyderabad.

The cost of treating angina in India costs 900 to 2000 dollars, which is almost a third of the other countries. You can simply contact us to get affordable treatment in the best hospitals in India.

What diagnoses and tests are done before IVF?

Before an IVF cycle begins using the couple’s own eggs and sperm, they will go through various screenings including

Test of ovarian reserve. To determine the quantity and quality of the eggs, the doctor can test the levels of follicle-stimulating hormone (FSH), estradiol (estrogen), and anti-Müllerian hormone in the blood during the first few days of the menstrual cycle.

Test results are often used in conjunction with an ovarian ultrasound, which helps predict how the ovaries will respond to fertility drugs.

Screening for infectious diseases. Both partners are screened for infectious diseases, including HIV.

seed analysis. If this is not done as part of the initial fertility assessment, the doctor will perform a semen analysis just prior to starting an IVF treatment cycle.

uterine examination. The doctor will examine the inner lining of the uterus before beginning IVF. This procedure involves sonohysterography, in which fluid is injected through the cervix into the uterus, and an ultrasound to create images of the uterine cavity. Or it could involve a hysteroscopy, in which a thin, flexible hysteroscope is inserted through the vagina and cervix into the uterus.

Practice embryo transfer. The doctor may perform a sham embryo transfer to determine the depth of the uterine cavity and the technique that is most likely to successfully transfer the embryos into the uterus.

(One also likes to read: Get Female Infertility Treatment in Delhi NCR )

What are the steps of IVF treatment?

During IVF treatment, a number of procedures are performed to treat fertility. All of these procedures are less invasive and must be performed sequentially at the right time. These procedures are:

  • birth control pills or estrogen
  • Ovarian Stimulation – Monitor/Trigger Shot
  • egg retrieval
  • fertilization
  • development of the embryo
  • embryo transfer
  • pregnancy

What are the benefits of IVF?

There are many other treatment methods, but IVF is the most common, but there are a few reasons for this, its advantages are:

  • Most beneficial for women over 35 years old
  • Less invasive
  • Reduce the chance of tube damage
  • Possibility to use chances of conception
  • Less chance of abortion/miscarriage
  • Options with donated eggs and/or sperm if required

List of the best fertility doctors in Hyderabad

If you are looking for a good treatment, you have come to the right place. We have partnerships with the best fertility doctor in Hyderabad offering you the best treatment at an affordable cost:

  • dr M.Niharika (Bogulkunta, Hyderabad) 10+ years of experience
  • dr NS Rani (Nagole, Hyderabad) has 12 years of experience
  • dr Fr. Rama Devi (Telangana, Hyderabad) has over 30 years of experience
  • dr Padmaja Divakar (Habsiguda, Hyderabad) has over 15 years of experience
  • dr Nirmalaa Agarwal (Telangana, Hyderabad) has over 30 years of experience
  • dr Kiran D Sekhar (Khairatabad and Hyderabad) has 12 years of experience
  • dr Naresh Sekhar (Khairatabad, Hyderabad) has 13 years of experience
  • dr Durga Rao (Banjara Hills, Hyderabad) has 18 years of experience
  • dr Durvasula Ratna (Banjara Hills, Hyderabad) has over 26 years of experience
  • dr Chandana Lakkireddi (Banjara Hills, Hyderabad) has over 20 years of experience

Best Fertility Doctor in Hyderabad by GoMedii.

Contact GoMedii to find out more about the treatment costs and facilities of the best fertility doctor in Hyderabad in India. To get frantic treatment in India make an inquiry on our website or you can too contact us on WhatsApp (+91 9654030724) Call us on (+91 9599004811) and you can also email us at [email protected] County Report.com. Our team will get back to you as soon as possible.

(One also likes to read: We offer you the best IVF and infertility treatment in India )


Disclaimer: GoMedii is a recognized and considerate healthcare platform that tends to connect every point of healthcare needs and institutions. GoMedii makes it easy for readers to access all health news, health tips and information from health professionals and doctors. All the information and facts mentioned in the GoMedii blog have been thoroughly checked and verified by the doctors and health experts, otherwise the source of the information for the same is confirmed.


About GoMedii: GoMedii is a healthcare technology platform that crafts your treatment/surgery the way you need and plan. A treatment partner that simplifies the patient journey at every step. Drop your questions to get the most affordable and premium treatment options. You can just download the GoMedii app Android or iOS.

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